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Consequently, coadministration of ozanimod with drugs which will raise norepinephrine or serotonin will not be suggested. Watch for hypertension with concomitant use.apalutamide will reduce the level or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a st